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The announcement that the VOICE (Vaginal and Oral Interventions to Control the Epidemic) study did not demonstrate protection against HIV in women prescribed daily tenofovir gel is a grave disappointment to CAPRISA. Professor Salim Abdool Karim, Director of CAPRISA, and Pro Vice-Chancellor (Research) at the University of KwaZulu-Natal, who is a site investigator in the VOICE trial, said that “These results were totally unexpected as there is good evidence from laboratory research, animal studies and human trials showing that tenofovir gel prevents HIV. However, science does not always produce the answer we hope for. This is particularly pertinent when a drug’s effectiveness is dependent on a complex combination of the biological activity of the drug and the human behaviour influencing use of the drug as prescribed during the study. I look forward to seeing the complete results and, in particular, an analysis of whether the drug levels in the female genital tract provides any clues to the study’s outcome.”
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PARTNER INSTITUTIONS

National Institute for Communicable Diseases

CAPRISA is an official research institute of the University of KwaZulu-Natal and Columbia University.

CAPRISA was established in 2002 through a CIPRA grant from the NIH, as a multi-institutional collaboration, incorporated as an independent non-profit AIDS Research Organization.

CENTER FOR THE AIDS PROGRAMME OF RESEARCH IN SOUTH AFRICA

CAPRISA was created in 2001 and formally established in 2002 under the NIH-funded Comprehensive International Program of Research on AIDS (CIPRA) by five partner institutions; University of KwaZulu-Natal, University of Cape Town, University of Western Cape, National Institute for Communicable Diseases, and Columbia University in New York. CAPRISA is a designated UNAIDS Collaborating Centre for HIV Prevention Research. The main goal of CAPRISA is to undertake globally relevant and locally responsive research that contributes to understanding HIV pathogenesis, prevention and epidemiology as well as the links between tuberculosis and AIDS care.
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